Shortly after 6.30am police were called to reports of a collision on the A49 Winwick Road, between Cromwell Avenue and junction nine of the M62.
Officers attended the scene and found there had been a collision between a car and a cyclist near to Motormill car showroom.
The cyclist is believed to have sustained serious injuries and has been taken to hospital.
The diver of the car, a 41-year-old local man, has been arrested on suspicion of a number of offences including drug driving and possession of a Class A drug.
The road is currently closed northbound as a result of the incident and motorist are advised to avoid the area.
Anyone with any information in relation to the collision is asked to contact Cheshire Police on 101 quoting IML-709844.